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Open spaces, voids and large glass facades: many wishes require changes to the load-bearing structure. That is almost always possible, provided it is well prepared.
Always a structural engineer
Removing or modifying load-bearing elements requires calculations. The structural engineer determines how the load is carried, for example with steel beams and columns.
Foundations and existing condition
New point loads have to go somewhere. That is why the foundations are assessed too — especially in older buildings.
Permit
Structural changes often require a permit. Check this in advance via the Omgevingsloket or have your design partner look into it.
Execution
Propping, placing beams and only then demolishing: the order is essential for safety.